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Associative Experimental Design (AED) for Protein Crystallization Screening

Associative Experimental Design (AED) is an optimization method that includes eliminating prohibited combinations and prioritizing reagents based on AED analysis of results from protein crystallization experiments. AED generates candidate cocktails based on these initial screening results. These results are analyzed to determine those screening factors in chemical space that are most likely to lead to higher scoring outcomes, crystals.

PUBLICATIONS

1. İ. Dinç, M. L. Pusey and R. S. Aygün, "Optimizing Associative Experimental Design for Protein Crystallization Screening," in IEEE Transactions on NanoBioscience, vol. 15, no. 2, pp. 101-112, March 2016.  https://doi.org/10.1109/TNB.2016.2536030 

2. Dinç İ., Pusey M.L., Aygün R.S. (2015) Protein Crystallization Screening Using Associative Experimental Design. In: Harrison R., Li Y., Măndoiu I. (eds) Bioinformatics Research and Applications. ISBRA 2015. Lecture Notes in Computer Science, vol 9096. Springer, Cham https://doi.org/10.1007/978-3-319-19048-8_8

ADDRESS
Computer Science Department
Technology Hall (OKT) N360
University of Alabama in Huntsville
Huntsville, AL 35899

CONTACT
Email: ramazan dot aygun at uah dot edu
Phone: +1 (256) 824 6455
Fax: +1 (256)824 6239